RESUMEN
Pharmacological interventions are emerging as potential avenues of alleviating age-related disease. However, the knowledge of ongoing clinical trials as they relate to aging and pharmacological interventions is dispersed across a variety of mediums. In this review we summarize 136 age-related clinical trials that have been completed or are ongoing. Furthermore, we establish a database that describe the trials (AgingDB, www.agingdb.com) keeping track of the previous and ongoing clinical trials, alongside their outcomes. The aim of this review and database is to give people the ability to easily query for their trial of interest and stay up to date on the latest results. In sum, herein we give an overview of the current pharmacological strategies that have been applied to target human aging.
Asunto(s)
Envejecimiento , Humanos , Estudios LongitudinalesRESUMEN
Las anomalías dentales son un grupo de alteraciones morfológicas, que se pueden expresar en la corona o en la raíz dental; aparecen durante el desarrollo de los órganos dentales, se ha establecido que tienen un componente genético y molecular importante. También se han planteado influencias medioambientales, traumáticas y microbiológicas. Las anomalías morfológicas dentarias son comunes, y se presentan con una incidencia de 74,7% según Freer (1998). Los dientes cónicos, en clavija o reducidos tienen una incidencia menor y muestran mayor incidencia en dentición permanente, así como en los incisivos laterales superiores. El mencionado defecto va a ser origen de alteraciones en la oclusión, la longitud de arco, compromisos estéticos que van a afectar la autoestima del paciente. El propósito de este trabajo es presentar dos casos de dientes cónicos, uno en dentición permanente, otro en dentición temporal relacionándolos con el marco teórico encontrado en la literatura sobre las influencias genéticas que juegan un papel importante en la aparición de la mencionada anomalía, aunque no se pudo realizar el estudio genético que se quisiera a causa limitaciones económicas.
Dental anomalies are a group of morphological alterations of the teeth, which can be expressed in the tooth crown or root and appear during tooth development. It has been established to have a strong molecular and genetic component. There also have been proposed environmental, traumatic and microbiological influence. Dental morphological anomalies are common with an incidence of 74.7% according to Freer (1998). The alteration known as conical teeth, peg-shaped teeth or reduced teeth show a more reduced incidence and are most commonly found in the permanent dentition and upper lateral incisors. This defect is associated with impaired occlusion alteration, arc length anomalies, aesthetic and self-esteem. The purpose of this paper is to present two cases of conical teeth, one in permanent dentition and another in temporary dentition and its relationship to the theory found in the literature regarding genetic influences that plays an important role in the presentation of this anomaly. Not genetic studies were performed because of the economic factor.
